First Reports of Adverse Drug Reactions (ADRs) in Recent Weeks
First Reports of Adverse Drug Reactions (ADRs) in Recent Weeks
The following table contains an overview of first published case reports of adverse drug reactions identified in the international literature in recent weeks. Any claim to a 'first report' is verified by a database search of previous literature.
Serious: an event is serious (FDA MedWatch definition) when the patient outcome is death, life-threatening, hospitalisation, disability, congenital anomaly, or requires intervention to prevent permanent impairment or damage.
The following table contains an overview of first published case reports of adverse drug reactions identified in the international literature in recent weeks. Any claim to a 'first report' is verified by a database search of previous literature.
| Ceftriaxone/cefepime/ceftazidime: status epilepticus in patients with renal failure | Martinéz-Rodríguez JE, Barriga FJ, Santamaria J, et al. Nonconvulsive status epilepticus associated with cephalosporins in patients with renal failure. Am J Med 2001 Aug; 111: 115-9 |
| Celecoxib: Sweet's syndrome | Fye KH, Crowley E, Berger TG, et al. Celecoxib-induced Sweet's syndrome. J Am Acad Dermatol 2001 Aug; 45: 300-2 |
| Chlorhexidine: allergic contact balanitis | Barrazza V. Connubial allergic contact balanitis due to chlorhexidine. Contact Dermat 2001 Jul; 45: 42 |
| Cyclosporin/prednisone: fatal angiosarcoma (serious) | Schulze R, Schulze M, SalomonDani A, et al: Metastatic angiosarcoma of the right atrium during cyclosporin and prednisone immunosuppression after kidney transplantation. Internist 2001 Jan; 42: 119-23 |
| Diltiazem: postoperative heamorrhage (serious) | Yesudian PD, Velangi SS, Velangi MR, et al. Postopeartive bleeding in a patient on diltiazem. Br J Dermatol 2001 Jul; 145 Suppl. 59: 87 |
| Eptifibatide/alteplase: haemorrhage in an elderly patient | Singh S, Methot M, LaHaye S, et al. Complications associated with glycoprotein IIB/IIIA antagonists after thrombolysis. Can J Hosp Pharm 2001; 54: 152 |
| Isotretinoin: onycholysis, cheilitis, nail fragility | Önder M, Öztas MO, Öztas P. Isotretinoin-induced nail fragility and onycholysis. J Dermatol Treat 2001 Jun; 12: 115-6 |
| Meropenem: allergic contact dermatitis | Yesudian PD, King CM. Occupational allergic contact dermatitis from meropenem. Contact Dermat 2001 Jul; 45: 53 |
| Paclitaxel: ischaemic colitis | Daniele B, Rossi GB, Losito S, et al. Ischemic colitis associated with paclitaxel. J Clin Gastroenterol 2001 Aug: 33: 159-60 |
| Rituximab: fatal reactivation of cytomegalovirus infection (serious) | Suzan F, Ammor M, Ribrag V. Fatal reactivation of cytomegalovirus infection after use of rituximab for a post-transplantation lymphoproliferative disorder. NEJM 2001 Sep; 345: 1000 |
| Sildenafil: heamorrhoidal haemorrhage | Sheikh RA, Yasmeen S, Prindiville TP. Hemorrhoidal bleeding associated with sildenafil. Am J Gastroenterol 2001 Aug; 96: 2518-19 |
| Sirolimus: femoral head necrosis (serious) | Bhandari S, Eris J. Premature osteonecrosis and sirolimus treatment in renal transplantation. BMJ 2001 Sep; 323; 665 |
| Trastuzumab: heart failure (serious) | Strasser F, Betticher DC, Suter TM. Trastuzumab and breast cancer. NEJM 2001 Sep; 345: 996 |
Serious: an event is serious (FDA MedWatch definition) when the patient outcome is death, life-threatening, hospitalisation, disability, congenital anomaly, or requires intervention to prevent permanent impairment or damage.
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