Cost-effectiveness of Asenapine for Bipolar Disorder
Cost-effectiveness of Asenapine for Bipolar Disorder
Over a five-year time period, asenapine was found to be a dominant strategy over olanzapine in the treatment of BPD, from both a MoH and a societal perspective (Table 3). Thus, the costs associated with the use of asenapine are lower than those associated with the use of olanzapine, and the number of QALYs obtained with asenapine is higher than the number obtained with olanzapine. Per 1,000 patients, there was a gain of 84.84 QALY with the use of asenapine and a decrease in cost of Can$3,847,300 from a MoH perspective and a decrease of Can$3,878,343 from a societal perspective.
From both MoH and societal perspectives, asenapine remained a dominant alternative over a ten-year time horizon (Table 3).
Results of the deterministic and probabilistic analyses confirmed the robustness of the base-case results. According to the deterministic analysis results, asenapine remained a dominant strategy from both perspectives. The individual variation of each parameter had no impact on the base-case results. The probabilistic sensitivity analysis also confirmed the robustness of the base-case results. From both a MoH and a societal perspective, asenapine was a dominant alternative over olanzapine in 99.2% of the Monte Carlo simulations.
Results
Base-case Analysis
Over a five-year time period, asenapine was found to be a dominant strategy over olanzapine in the treatment of BPD, from both a MoH and a societal perspective (Table 3). Thus, the costs associated with the use of asenapine are lower than those associated with the use of olanzapine, and the number of QALYs obtained with asenapine is higher than the number obtained with olanzapine. Per 1,000 patients, there was a gain of 84.84 QALY with the use of asenapine and a decrease in cost of Can$3,847,300 from a MoH perspective and a decrease of Can$3,878,343 from a societal perspective.
Complementary Analyses
From both MoH and societal perspectives, asenapine remained a dominant alternative over a ten-year time horizon (Table 3).
Sensitivity Analysis
Results of the deterministic and probabilistic analyses confirmed the robustness of the base-case results. According to the deterministic analysis results, asenapine remained a dominant strategy from both perspectives. The individual variation of each parameter had no impact on the base-case results. The probabilistic sensitivity analysis also confirmed the robustness of the base-case results. From both a MoH and a societal perspective, asenapine was a dominant alternative over olanzapine in 99.2% of the Monte Carlo simulations.
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