The Role of the Circadian Clock in Rheumatoid Arthritis
The Role of the Circadian Clock in Rheumatoid Arthritis
The biological clock regulates many aspects of the immune system. As a consequence, immune responses often demonstrate measurable circadian variation. Several lines of evidence highlight the contribution of the circadian clock to the function of the immune system. Firstly, multiple immune cells possess the clockwork machinery and show daily variation in their function. Secondly, disruption of the circadian clock has a detrimental effect on the function of the immune system. Finally, deletion of core clock genes can impact on immune responses. These established interactions between the clock and the immune system all have implications for RA.
Circadian Regulation of the Immune System
The biological clock regulates many aspects of the immune system. As a consequence, immune responses often demonstrate measurable circadian variation. Several lines of evidence highlight the contribution of the circadian clock to the function of the immune system. Firstly, multiple immune cells possess the clockwork machinery and show daily variation in their function. Secondly, disruption of the circadian clock has a detrimental effect on the function of the immune system. Finally, deletion of core clock genes can impact on immune responses. These established interactions between the clock and the immune system all have implications for RA.
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