The Efficacy of Duloxetine, NSAIDs, and Opioids in OA
The Efficacy of Duloxetine, NSAIDs, and Opioids in OA
This meta-analysis found no difference between duloxetine and other post-first line oral treatments for OA in the total WOMAC score after approximately 12 weeks of treatment in a consistent manner. Etoricoxib was more effective than duloxetine in the frequentist analysis and resulted in a 96% probability of being better than duloxetine in the nonadjusted Bayesian analysis. After adjustment for baseline pain score, however, duloxetine showed evidence of superiority to both tramadol and hydromorphone, but not for the other treatments, including etoricoxib.
Conclusions
This meta-analysis found no difference between duloxetine and other post-first line oral treatments for OA in the total WOMAC score after approximately 12 weeks of treatment in a consistent manner. Etoricoxib was more effective than duloxetine in the frequentist analysis and resulted in a 96% probability of being better than duloxetine in the nonadjusted Bayesian analysis. After adjustment for baseline pain score, however, duloxetine showed evidence of superiority to both tramadol and hydromorphone, but not for the other treatments, including etoricoxib.
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