• Sadness is oppressive with endogenous depressionImage by Flickr.com, courtesy of Sara Bj?rk
  
  

Signs

• Signs are what a doctor observes about a patient with endogenous depression. These include significant weight changes, a change in the patient's ability to concentrate and lack of personal grooming.
  
  

Physical Symptoms

• According to the Mayo Clinic, a patient with major depression may feel tired all of the time, have changes in appetite and sleep patterns and chronic pains.
  
  

Emotional Symptoms

• According to the National Alliance for Mental Health (NAMI), a patient with major depression feels lack of interest in anything, feels hopeless, guilty, sad, angry, constant frustration and suicidal.
  
  

Time Frame

• According to "The Family Intervention Guide to Mental Illness: Recognizing Symptoms & Getting Treatment" by Bodie Morey and Kim T. Muesser, signs and symptoms of endogenous depression last for more than two weeks.
  
  

Significance

• A person with major depression may think he is beyond help and will not go seek it. It may be up to a friend or family member to make the person go get help.