Targeting Reperfusion Injury in the Era of Primary PCI

Conclusions

STEMI remains a major cause of mortality and morbidity and further infarct-sparing treatments are needed. Conditioning prevents reperfusion injury in experimental studies, but most strategies fail in clinical studies, highlighting the importance of focus on study design. Nevertheless, some treatments have demonstrated cardioprotection, but hitherto no large randomised study has demonstrated any effect on outcome, but ongoing studies that address this issue are underway.